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嘌呤霉素,G-418,酶抑制剂,基因选择,抗生素和蛋白质纯化试剂
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公司介绍
AG Scientific始建于1997年,总部位于美国加利福尼亚州的圣迭戈。 力求为生命科学研究界提供最具创新性和高质量的生化试剂 。公司客户遍布分子生物学,神经生物学, 细胞生物学,癌症研究 ,药物研发,农业生物技术和动物健康且在迅速增长。 AG Scientific以诊断化学品,医疗器械试剂和下游生物加工试剂为起始原料。AG Scientific已经成功的生产和供应新颖的发酵和自然衍生产品,包括酶抑制剂,基因选择,抗生素和蛋白质纯化试剂。AG Scientific, Inc. was fo...

AG Scientific/Aphidicolin/1 mg/A-1026-1 mg

AG Scientific/Aphidicolin/1 mg/A-1026-1 mg
  • AG Scientific/Aphidicolin/1 mg/A-1026-1 mg
商品介绍
More Information
Alternate Name/Synonyms
APC; ICI 69653; NSC 234714
SKU
A-1026
CAS #
38966-21-1
Chemical Name
(1S,2S,5R,6R,7R,10S,12R,13R)-6,13-bis(hydroxymethyl)-2,6-dimethyltetracyclo[10.3.1.01,10.02,7]hexadecane-5,13-diol
Chemical Formula
C20H34O4
Molecular Weight
338.5 Da
Appearance
White Powder
Purity
>99% (TLC)
Solubility
Methanol: Clear colorless solution at 10 mg/ml
Melting Point
230°C
Preparation
N/A
Storage Temp
+4°C
THERAPEUTIC AREA
Not Available
USE
For research use only. Not intended for diagnostic or therapeutic use. Aphidicolin is a tetracyclic diterpene with antibiotic, antiviral and antimitotic properties by blocking the cell cycle at early S-phase. This property has been used to synchronise cell division and is useful as a tool in cell differentiation research. Aphidicolin induces apoptosis, prolongs the half-life of DNA methyltransferase, is active against Leishmania parasites and acts synergistically with the antitumor agents, vincristine and doxorubicin.
Merck Index
Merck Index: 13.734.2001
MDL NUMBER
MFCD00083214
CHEMACX
X1001937-7
INCHI
InChI=1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1
SMILES
C[C@]12CC[C@H]([C@@]([C@@H]1CC[C@@H]3[C@@]24CC[C@@]([C@H](C3)C4)(CO)O)(C)CO)O
Peptide sequence
Not Applicable
RTECS
PB9185000
UN #"S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Warning.Toxic. Potential Carcinogenic. Do not use this compound if you are not fully trained or are unaware of the hazards involved. Wear gloves/mask when handling product. Avoid contact by all means of exposure. Avoid contact with skin, eyes or clothing. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Use with local exhaust ventilation.
Citations
CELL BIOLOGY:Sororin cooperates with the acetyltransferase Eco2 to ensure DNA replication-dependent sister chromatid cohesionAndrea L. Lafont, Jianhua Song, and Susannah RankinPNAS, Nov 2010; 107: 20364 - 20369.
Citations_Hyperlink
http://www.pnas.org/cgi/reprint/107/47/20364
Certificate of Analysis 1
A-1026, J1034E.pdf
Certificate of Analysis 2
A-1026, J1034D.pdf
Certificate of Analysis 3
A-1026, J1034C.pdf
品牌介绍

AG Scientific始建于1997年,总部位于美国加利福尼亚州的圣迭戈。 力求为生命科学研究界提供最具创新性和高质量的生化试剂 。公司客户遍布分子生物学,神经生物学, 细胞生物学,癌症研究 ,药物研发,农业生物技术和动物健康且在迅速增长。 AG Scientific以诊断化学品,医疗器械试剂和下游生物加工试剂为起始原料。AG Scientific已经成功的生产和供应新颖的发酵和自然衍生产品,包括酶抑制剂,基因选择,抗生素和蛋白质纯化试剂。

AG Scientific, Inc. was founded in 1997 in San Diego, CA with the purpose of Accelerating Scientific DiscoveryTM. We strive to produce the most innovative and highest quality biochemicals available to the life science research community. The scientists we are privileged to have as customers are making significant advancements in molecular biology, neurobiology, cell biology, cancer research, drug discovery, agricultural biotechnology and animal health.

AG Scientific has grown to provide starting materials for critical diagnostic chemicals, medical device reagents and downstream bioprocessing reagents. AG Scientific has demonstrated particular success in producing and supplying novel fermentation and naturally derived products including enzyme inhibitors, gene selection antibiotics, and reagents for protein purification.


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